prikaz prve stranice dokumenta Reakcije kvaternizacije izonikotinamida po principima zelene kemije
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undergraduate thesis
Reakcije kvaternizacije izonikotinamida po principima zelene kemije
2020. urn:nbn:hr:109:466903
Tomičić, Vice
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Department of Applied Chemistry and Ecology
Sub-department of Chemistry and Ecology

Cite this document

Tomičić, V. (2020). Reakcije kvaternizacije izonikotinamida po principima zelene kemije (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY. Retrieved from https://urn.nsk.hr/urn:nbn:hr:109:466903

Tomičić, Vice. "Reakcije kvaternizacije izonikotinamida po principima zelene kemije." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2020. https://urn.nsk.hr/urn:nbn:hr:109:466903

Tomičić, Vice. "Reakcije kvaternizacije izonikotinamida po principima zelene kemije." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2020. https://urn.nsk.hr/urn:nbn:hr:109:466903

Tomičić, V. (2020). 'Reakcije kvaternizacije izonikotinamida po principima zelene kemije', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, accessed 31 January 2025, https://urn.nsk.hr/urn:nbn:hr:109:466903

Tomičić V. Reakcije kvaternizacije izonikotinamida po principima zelene kemije [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY; 2020 [cited 2025 January 31] Available at: https://urn.nsk.hr/urn:nbn:hr:109:466903

V. Tomičić, "Reakcije kvaternizacije izonikotinamida po principima zelene kemije", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, Osijek, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:109:466903

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Metadata
TitleReakcije kvaternizacije izonikotinamida po principima zelene kemije
Title (english)Quaternization Reactions of Isonicotinamide According to the Principles of Green Chemistry
AuthorVice Tomičić
MentorValentina Bušić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
(Department of Applied Chemistry and Ecology)
(Sub-department of Chemistry and Ecology)
Osijek
Defense date and country2020-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
U ovom radu cilj bio je ispitati primjenu eutektičkih otapala na bazi kolin-klorida te primjenu ultrazvuka u sintezi kvaternih derivata izonikotinamida. Teorijski dio rada obuhvaća svojstva i primjenu eutektičkih otapala i ultrazvuka u organskoj sintezi, kvaterne amonijeve spojeve, njihova svojstva, potencijalnu biološku aktivnost i primjenu istih u znanosti i industriji. Eksperimentalni dio rada obuhvaća sintezu kvaternih derivata izonikotinamida metodama po principima zelene kemije. Rezultati pokazuju kako su skoro sva ispitana eutektička otapala dobar alternativni medij za kvaternizaciju izonikotinamida i supstituiranih 2-bromacetofenona. Najveće je iskorištenje (96 %) dobiveno u reakciji kvaternizacije izonikotinamida i 2, 4-dibromacetofenona u eutektičkom otapalu ChCl : oksalna kiselina 1 : 1. Ultrazvučnom su metodom uglavnom dobivena slična iskorištenja u odnosu na konvencionalnu metodu pri čemu je u reakciji kvaternizacije izonikotinamida i 2, 4'-dibromacetofenona u eutektičkom otapalu ChCl : oksalna kiselina 1 : 1 postignuto najviše iskorištenje (94 %).
Abstract (english)
In this paper, the goal was to examine the use of choline chloride-based eutectic solvents and the use of ultrasound in the synthesis of quaternized isonicotinamide derivatives. The theoretical part will discuss the properties and applications of eutectic solvents and ultrasound in organic synthesis, as well as quaternary ammonium compounds, their properties, potential biological activity and their application in science and industry. The experimental part of the paper, the synthesis of quaternized isonicotinamide derivatives, includes methods in accordance with the principles of green chemistry. The results show that almost all eutectic solvents tested are a good alternative medium for the quaternization of isonicotinamide and substituted 2-bromoacetophenones. The highest yield (96%) was obtained in the quaternization reaction of isonicotinamide and 2,4’-dibromoacetophenone in the eutectic solvent ChCl: oxalic acid 1: 1. The ultrasound method generally yielded similar yields as the conventional method, where the quaternization reaction of isonicotinamide and 2,4’-dibromacetophenone in the eutectic solvent ChCl: oxalic acid 1: 1 gave the highest yield (94%).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:109:466903
ProjectNumber: UIP-2017-05-6593
Title: Zelene tehnologije u sintezi heterocikličkih spojeva
Acronym: GREENNESS
Leader: Maja Molnar
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: UIP
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
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Created on2020-10-26 13:16:44