undergraduate thesis
Folic Acid and Pregnancy

Vlatka Matoković (2013)
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Department of Food and Nutrition Research
Sub-department of Nutrition
Metadata
TitleFolna kiselina u trudnoći
AuthorVlatka Matoković
Mentor(s)Ines Banjari (thesis advisor)
Abstract
Folna kiselina je vitamin B skupine (B9 vitamin). Topljiva je u vodi. U hrani se nalazi u nekom od reduciranih oblika pteroilglutaminske kiseline, tj. u obliku folata, a u suplemntima je to pteroilmonoglutaminska kiselina. Uloga folata u organizmu je višestruka. Tako su folati odgovorni za normalnu staničnu diobu i sudjeluju u sintezi velikog broja različitih stanica. Potrebni su za pravilno funkcioniranje mozga, mentalno i emocionalno zdravlje, imaju ulogu u kontroli razine homocisteina u krvi i u metabolizmu i stvaranju energije. Posebno je važna u trudnoći jer njen deficit može uzrokovati pobačaje i kongenitalne anomalije. Dva najčešća ozbiljna porođajna defekta mozga i kralježnice su spina bifida i anencefalija. Ti defekti pojavljuju se kada se dio neuralne cijevi, koja se kasnije razvija u mozak i kralježničku moždinu, ne zatvori. Zatvaranje se obično događa oko 24. dana nakon začeća, prije nego žena shvati da je trudna. Rezultati studija su pokazali da upotreba dodataka prehrani folne kiseline ili multivitamina koji sadrže i folnu kiselinu tijekom trudnoće, može smanjiti rizik od defekata neuralne cijevi za 40 do čak 80%. Također, učinkovitija prevencija defekata neuralne cijevi mogla bi se postići uvođenjem obogaćivanja hrane folnom kiselinom jer dnevne potrebe obično nisu zadovoljene samo unosom hrane. U odsutnosti obaveznog obogaćivanja, trebale bi se provoditi nacionalne kampanje koje bi pojačale znanje i upotrebu folne kiseline među ženama. Porodničari, pedijatri i liječnici opće prakse isto imaju važnu ulogu u informiranju i motiviranju žena da uzimaju dodatke prehrani folne kiseline prije začeća.
Keywordsfolates deficiency pregnancy neural tube defects food fortification folic acid supplements
Parallel title (English)Folic Acid and Pregnancy
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Lower level organizational unitsDepartment of Food and Nutrition Research
Sub-department of Nutrition
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineBIOTECHNICAL SCIENCES
Food Technology
Food Safety and Quality
Study programme typeuniversity
Study levelundergraduate
Study programmeFood Technology
Academic title abbreviationuniv. bacc. ing. techn. aliment.
Genreundergraduate thesis
Language Croatian
Defense date2013-09-30
Parallel abstract (English)
Folic acid is one of B group vitamins (B9 vitamin). It is water soluble. In food it is found in reduced form as pteroilglutamic acid, in folate form, and in supplements comes as pteroilmonoglutamic acid. Folates have multiple roles in organism. They are responsible for the normal cell differentiation and participate in synthesis of great number of different cells. They are also necessary for the proper brain functioning, mental and emotional health, play role in control of the homocysteine level and in metabolism and energy generation. Folic acid is especially important in pregnancy because its deficiency can cause miscarriages and congenital anomalies. The two most common birth defects of the brain and spine are spina bifida and anencephaly. These neural tube defects occur when part of the neural tube, which later develops into spinal cord and brain, does not close. Closing normally happens around 24th day after the conception, before a woman realises she is pregnant. Results of the studies have shown that the periconceptional use of supplements with folic acid alone, or multivitamins combined with folic acid, can lower the risk of neural tube defects by 40% up to 80%. Also, more effective prevention of neural tube defects could be achieved by initiation of food fortification with folic acid because daily requirements are usually not satisfied only by food intake. In the absence of mandatory fortification, national campaigns to increase knowledge and use of folic acid among women should be intensified and adequately funded. Obstetricians, paediatricians, and general practitioners can play an important part in informing and motivating women to take folic acid supplements preconception.
Parallel keywords (Croatian)folati deficit trudnoća defekti neuralne cijevi obogaćivanje hrane dodaci prehrani folne kiseline
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:109:677707
CommitterIvana Šuvak