master's thesis
Design and synthesis of new azetidinone based on 7-hydroxycoumarin

Ivana Odak (2013)
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Department of Applied Chemistry and Ecology
Sub-department of Chemistry and Ecology
Metadata
TitleDizajn i sinteza novih azetidinona na bazi 7-hidroksikumarina
AuthorIvana Odak
Mentor(s)Milan Čačić (thesis advisor)
Abstract
Kumarin (2H-kromen-2-on) i njegovi derivati su vrlo važna skupina heterocikličkih organskih spojeva koji se nalaze u različitim biljnim vrstama, a posjeduju širok spektar bioloških aktivnosti. Zbog izražene biološke aktivnosti intenzivno se istražuju novi putevi i metode sinteze najrazličitijih heterocikličkih prstenastih sustava s kumarinskom jezgrom. Posebna pozornost ovog rada usmjerena je na dizajn i sintezu novih azetidinona na bazi 7- hidroksikumarina. Azetidinoni, poznatiji kao β-laktami, izuzetno su važni heterociklički spojevi u organskoj i farmaceutskoj kemiji. Biološka aktivnost azetidinona pripisuje se prisutnošću β-laktamskog prstena u njihovoj strukturi. Dobiveni spojevi su pročišćeni prekristalizacijom, te su im određene točke tališta i elementarni sastav. Struktura novosintetiziranih spojeva potvrđena je elementarnom mikroanalizom, te 1H-NMR, IR spektrometrijom i spektrometrijom masa.
Keywordscoumarine azetidinones β-lactams biological activity
Parallel title (English)Design and synthesis of new azetidinone based on 7-hydroxycoumarin
Committee MembersIvica Strelec
Milan Čačić
Jurislav Babić
Daniela Čačić Kenjerić
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Lower level organizational unitsDepartment of Applied Chemistry and Ecology
Sub-department of Chemistry and Ecology
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineBIOTECHNICAL SCIENCES
Food Technology
Engineering
Study programme typeuniversity
Study levelgraduate
Study programmeFood Technology and Process Engineering
Academic title abbreviationdipl. ing.
Genremaster's thesis
Language Croatian
Defense date2013-11-07
Parallel abstract (English)
Coumarin (2H-chromen-2-one) and its derivatives are important group of heterocyclic organic compounds found in many different plant species. They possess a wide spectrum of biological activities and thus the synthesis of various coumarin nucleus-countaining heterocyclic ring systems are intensively explored. This paper gives special attention to design and synthesis of new azetidinone-based 7-hydroxycoumarin derivatives. Azetidinones, also known as β-lactams, are exteremely important heterocyclic compounds in organic and pharmaceutical chemistry. Biological activity of azetidinones is attributed to the presence of β-lactam ring in their structure. The reaction progress was monitored with a thin layer chromatography, novel compounds were purified by recrystallization and the melting points were determined, as well as their structure. The structure of newly synthesized compounds is confirmed by elemental microanalysis, 1H-NMR, IR spectrometry and mass spectrometry.
Parallel keywords (Croatian)kumarini azetidinoni β-laktami biološka aktivnost
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:109:770044
CommitterSanda Hasenay