master's thesis
Synthesis of thiadizine with the coumarine core as a potential growth inhibitor of some mycotoxigen moulds

Vesna Grabar (2010)
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Sub-department of Applied Chemistry and instrumental Methods
Metadata
TitleSinteza tiadiazina s kumarinskom jezgrom kao potrencijalnih inhibitora rasta nekih mikotoksikogenih plijesni
AuthorVesna Grabar
Mentor(s)Milan Čačić (thesis advisor)
Abstract
Derivati kumarina (2H-kromen-2-ona) su heterociklički spojevi, a mnogi od njih imaju izražene biološke aktivnosti. Sadrže 2-pironsku jezgru kondenziranu sa benzenskim prstenom. Uglavnom se nalaze u biljnim vrstama. Spojevi s kumarinskom jezgrom su zbog svog inhibitornog djelovanja na rast određenih mikroorganizama našli primjenu u medicini, prehrambenoj i farmaceutskoj industriji. Posebna pozornost ovog rada je usmjerena na dizajn i sintezu novih tiadiazina iz supstituiranih kumarinskih tiosemikarbazida. Tiadiazini su također biološki aktivni spojevi s antivirusnim, antitumornim, antituberkuloznim i drugim djelovanjima. Reakcijom kondenzacije 3--bromoacetilkumarina sa odgovarajućim tiosemikarbazidima priređeni su različiti tiadiazini koji dosad nisu opisani u literaturi. Dobiveni spojevi su pročišćeni prekristalizacijom te su im određene točke tališta i elementarni sastav. Struktura pojedinih spojeva potvrđena je 1H-NMR i IR spektrometrijom te spektrometrijom masa.
Keywordscoumarin thiadiazine mycotoxine
Parallel title (English)Synthesis of thiadizine with the coumarine core as a potential growth inhibitor of some mycotoxigen moulds
Committee MembersIvica Strelec
Milan Čačić
Lidija Jakobek
Jurislav Babić
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Lower level organizational unitsSub-department of Applied Chemistry and instrumental Methods
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineBIOTECHNICAL SCIENCES
Food Technology
Engineering
Study programme typeuniversity
Study levelgraduate
Study programmeFood Technology and Process Engineering
Academic title abbreviationdipl. ing.
Genremaster's thesis
Language Croatian
Defense date2010-05-14
Parallel abstract (English)
The coumarine derivatives (2H-chromen-2-ones) are heterocyclic compounds, many of whom have significant biological activities. They contain 2-pyrone core that is condensed with the benzen ring. They can mostly be found in herbal species.Coumarine core based compounds are very useful in medicine, food and pharmaceutical industry, due to its specific inhibitory effects on the growth of specific microorganisms. This paper focuses special attention on the design and synthesis of the new thiadiazine from substitued coumarine thisemicarbazides. Thiadizine are also biologicly active compounds with antiviral, antitumor, antituberculosis and other effects. By reacting the condensed 3--bromoacetylcoumarine with the matching thiosemicarbazides, there were some varieties of thiadiazine created that have not been described in literature. The reaction progress was monitored with a thin layer chromotography, the attained compounds were purified by recrystallization and the specific points of melting, as well as their composition, were determined. The structure of particular compounds was confirmed with 1H-NMR i IR spectrometry, as well as with mass spectrometry.
Parallel keywords (Croatian)kumarin tiadiazin mikotoksini
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:109:495276
CommitterIvana Šuvak