prikaz prve stranice dokumenta Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase
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Scientific paper - Original scientific paper
Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase
Croatian journal of food science and technology, 9 (2017), 1; 57-65. https://doi.org/10.17508/CJFST.2017.9.1.08
Strelec, Ivica; Burić, Petar; Janković, Irena; Kovač, Tihomir; Molnar, Maja

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Strelec, I., Burić, P., Janković, I., Kovač, T. & Molnar, M. (2017). Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase. Croatian journal of food science and technology, 9. (1), 57-65. doi: 10.17508/CJFST.2017.9.1.08

Strelec, Ivica, et al. "Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase." Croatian journal of food science and technology, vol. 9, no. 1, 2017, pp. 57-65. https://doi.org/10.17508/CJFST.2017.9.1.08

Strelec, Ivica, Petar Burić, Irena Janković, Tihomir Kovač and Maja Molnar. "Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase." Croatian journal of food science and technology 9, no. 1 (2017): 57-65. https://doi.org/10.17508/CJFST.2017.9.1.08

Strelec, I., et al. (2017) 'Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase', Croatian journal of food science and technology, 9(1), pp. 57-65. doi: 10.17508/CJFST.2017.9.1.08

Strelec I, Burić P, Janković I, Kovač T, Molnar M. Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase. Croatian journal of food science and technology [Internet]. 2017 June 07 [cited 2025 April 05];9(1):57-65. doi: 10.17508/CJFST.2017.9.1.08

I. Strelec, P. Burić, I. Janković, T. Kovač and M. Molnar, "Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase", Croatian journal of food science and technology, vol. 9, no. 1, pp. 57-65, June 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:109:443755. [Accessed: 05 April 2025]

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Metadata
Title (english)Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase
AuthorIvica Strelec
AuthorPetar Burić
AuthorIrena Janković
AuthorTihomir Kovač
AuthorMaja Molnar
Author's institutionJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract (english)
Inhibitory effect of 32 coumarin derivatives (20 Schiff bases, 5 thiosemicarbazides, 5 thiazolidinones, and their precursors,7-hydroxy-4-methylcoumarin and 4-methylcoumarin-7-yl hydrazine carboxylate) on partially purified apple polyphenol oxidase was investigated. Thirteen coumarin derivatives inhibited polyphenol oxidase (5 Schiff bases, 5 thiosemicarbazides,1 thiazolidinone, 4-methyl-7-hydroxycoumarin and 4-methylcoumarin-7-yl hydrazine carboxylate), while 19 derivatives showed no effect on enzyme activity. The most effective inhibitors were thiosemicarbazides, with 4-methyl-1-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl) thiosemicarbazide (compound C23) being the most prominent inhibitor (IC50 = 10.45 µM). The importance of thiosemicarbazide moiety as crucial structure element for strong apple PPO inhibition was confirmed by its cyclisation to thiazolidinone bearing the same substituents as corresponding thiosemicarbazide. Capture of the sulphur atom of thiosemicarbazide group within tiazolidinone ring caused significant loss of inhibitory effect against apple PPO.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatian journal of food science and technology
Numberingvol. 9, no. 1, pp. 57-65
p-ISSN1847-3466
e-ISSN1848-9923
DOIhttps://doi.org/10.17508/CJFST.2017.9.1.08
URN:NBNurn:nbn:hr:109:443755
Publication2017-06-07
Document URLhttps://hrcak.srce.hr/182642
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2025-03-26 15:19:54