prikaz prve stranice dokumenta Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona
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master's thesis
Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona
2009. urn:nbn:hr:109:579486
Laslavić, Kristina
Josip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
Department of Applied Chemistry and Ecology
Sub-department of Chemistry and Ecology

Cite this document

Laslavić, K. (2009). Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY. Retrieved from https://urn.nsk.hr/urn:nbn:hr:109:579486

Laslavić, Kristina. "Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona." Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2009. https://urn.nsk.hr/urn:nbn:hr:109:579486

Laslavić, Kristina. "Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona." Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, 2009. https://urn.nsk.hr/urn:nbn:hr:109:579486

Laslavić, K. (2009). 'Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona', Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, accessed 14 April 2024, https://urn.nsk.hr/urn:nbn:hr:109:579486

Laslavić K. Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY; 2009 [cited 2024 April 14] Available at: https://urn.nsk.hr/urn:nbn:hr:109:579486

K. Laslavić, "Dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona", Master's thesis, Josip Juraj Strossmayer University of Osijek, FACULTY OF FOOD TECHNOLOGY, Osijek, 2009. Available at: https://urn.nsk.hr/urn:nbn:hr:109:579486

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Metadata
TitleDizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4-diona
Title (english)Design, syntesis and structure of some derivates 1,3-thiazolidine-2,4-dione
AuthorKristina Laslavić
MentorMilan Čačić (mentor)
Committee memberJurislav Babić
Committee memberMilan Čačić
Committee memberRužica Matešić-Puač
MBZ: 126601
Committee memberLidija Jakobek
GranterJosip Juraj Strossmayer University of Osijek
FACULTY OF FOOD TECHNOLOGY
(Department of Applied Chemistry and Ecology)
(Sub-department of Chemistry and Ecology)
Osijek
Defense date and country2009-10-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Engineering
Abstract
Tiazolidini su skupina heterocikličkih organskih spojeva sa zasićenim peteročlanim prstenom koji sadrži tioestersku i amino skupinu na 1- i 3- položaju. 1,3-Tiazolidin-2,4-dioni i njegovi derivati su skupina spojeva s različitim mogućnostima heterocikličkih modifikacija. Najviše se istražuju zbog širokog spektra farmakoloških svojstava. Metilenska skupina na petom položaju 1,3-tiazolidin-2,4-diona je najreaktivnija. Zbog toga se većina modifikacija na prstenu 1,3-tiazolidin-2,4-diona odvija u petom položaju i pri tome nastaju novi spojevi. Ovim radom istaknuti su dizajn, sinteza i struktura nekih derivata 1,3-tiazolidin-2,4- diona. Kao efikasna metoda za sintezu nekih derivata 1,3-tiazolidin-2,4-diona pokazala se Knoevenagel-ova kondenzacija. Knoevenagel-ovom kondenzacijom aktivne metilenske skupine na 5- položaju u 1,3-tiazolidin-2,4-dionima sa aldehidima nastaju 5-ariliden-2,4- tiazolidindioni. Tijek reakcije je praćen tankoslojnom kromatografijom. Dobiveni spojevi su pročišćeni prekristalizacijom, određene su im točke tališta i elementarni sastav. Stuktura pojedinih spojeva potvrđena je na temelju podataka dobivenih elementarnom mikroanalizom 1H NMR i IR spektrometrijom.
Abstract (english)
Thiazolidines are a group of heterocyclic organic compounds with saturated fivemembered ring containing tioether and amino group on the 1- and 3- position. 1,3-Thiazolidine-2,4-dione and its derivatives are a group of compounds with different capabilities of heterocyclic modifications. Most are investigated due to the wide spectrum of pharmacological properties. The most reactive group of 1,3-thiazolidine-2,4- dione is methylene group in the fifth position of the ring. Most modifications are performed in the fifth position of 1,3-thiazolidine-2,4-dione ring and therefore new compounds are synthesized. This paper highlights the design, synthesis and structure of some derivatives of 1,3- thiazolidine-2,4-dione. Knoevenagel condensation proved to be an efficient method for the synthesis of some derivatives of 1,3-thiazolidine-2,4-dione. Thiazolidinedione derivatives, 5 – aryliden-2,4-thiazolidinediones are synthesized by Knoevenagel condensation of an active methylene group with various aldehydes in the fifth position of the 1,3-thiazolidine-2,4-dione ring. The reactions were monitored using thin-layer chromatography. Products were purified by recrystalization, their melting points and elemental compositions were determined. Structure of the products has been deducted on the basis of elementary microanalysis data and 1H NMR and IR spectrometry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:109:579486
Study programmeTitle: Food Technology and Process Engineering
Study programme type: university
Study level: graduate
Academic / professional title: diplomirani inženjer prehrambene tehnologije i procesnog inženjerstva (diplomirani inženjer prehrambene tehnologije i procesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2015-12-02 13:39:01